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13 August 2017

Gene editing used in breakthrough result

Scientists have used gene editing to engineer mutant ant species.

IT MAY sound like a script for a science fiction movie, but scientists have created the world’s first mutant ants.

Two independent research teams have harnessed the gene editing technology CRISPR to genetically alter the ants. In one study, researchers at Rockefeller University modified a gene essential for sensing the pheromones that ants use to communicate. Experts say that the resulting deficiencies in the ants’ social behaviours and their ability to survive in a colony, sheds light on social evolution.

“It was well known that ant language is produced through pheromones, but now we understand a lot more about how pheromones are perceived,” said Daniel Kronauer, head of Rockefeller University’s Laboratory of Social Evolution and Behavior, in a statement.

“The way ants interact is fundamentally different from how solitary organisms interact, and with these findings we know a bit more about the genetic evolution that enabled ants to create structured societies.”

CRISPR, which has been compared to a pair of “molecular scissors,” lets scientists alter or replace specific sections of DNA.

Scientists used CRISPR to disrupt a gene known as Orco in the clonal raider ant, species Ooceraea biroi, but then faced the challenge of keeping the mutant ants alive. “We had to convince the colonies to accept the mutants. If the conditions weren’t right, the worker ants would stop caring for larvae and destroy them,” said Rockefeller University graduate fellow Waring Trible, in the statement. “Once the ants successfully made it to the adult phase, we noticed a shift in their behaviour almost immediately.”

While ants typically travel single file, researchers noticed that the mutant ants couldn’t fall in line, along with other behavioural abnormalities.

he results of the study are published in the journal Cell.

A separate study, also published in the journal Cell, saw scientists target the Orco gene in the Indian jumping ant, Harpegnathos saltator. Experts note that the Indian jumping ant is unlike other ant species because only the queen can mate and pass genes onto the next generation. However, any adult female worker of the species can become a “pseudo queen” in the queen’s absence.

The second study was led by researchers from New York University, NYU School of Medicine, Arizona State University, the University of Pennsylvania and Vanderbilt University.

Ant queens suppress the ability of female workers to mate and lay eggs, although if the queen is removed, the most aggressive females, after winning a series of antenna duels with rivals, can go on to lay eggs.

Scientists used CRISPR to disrupt a gene known as Orco in the clonal raider ant, species Ooceraea biroi, but then faced the challenge of keeping the mutant ants alive.

Scientists used CRISPR to disrupt a gene known as Orco in the clonal raider ant, species Ooceraea biroi, but then faced the challenge of keeping the mutant ants alive.Source:News Corp Australia

The study engineered three mutant ants to lack the Orco gene. Without the gene, females cannot process pheromones, making them less likely to engage in duelling.

“While ant behaviour does not directly extend to humans, we believe that this work promises to advance our understanding of social communication, with the potential to shape the design of future research into disorders like schizophrenia, depression or autism that interfere with it,” said Claude Desplan, professor at NYU’s Department of Biology, and one of the report’s authors, in a statement.

In a third related study by the University of Pennsylvania, scientists injected the brain chemical corazonin into ants transitioning to become a pseudo-queen, which simulated worker-like hunting behaviours, while inhibiting ‘pseudo-queen’ behaviour, such as duelling and laying eggs.

These results are also published in the journal Cell.

Gene editing has been generating plenty of buzz recently. Earlier this week, scientists announced the elimination of viruses in pigs that could be harmful to people, using the CRISPR technology. The discovery could potentially lay the foundations for pig-to-human organ transplants.

In another project, researchers used gene-editing to correct a disease-causing gene mutation in human embryos, preventing the mutation from passing to future generations. In the stunning discovery, a research team led by Oregon Health and Science University reported that embryos can fix themselves if scientists jump-start the process early enough.

This article originally appeared on Fox News.

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